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STAT3 Rabbit monoclonal antibody

货号: MB66276

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66276

Product Name :STAT3 Rabbit monoclonal antibody

Swiss-Prot :P40763

Host :Rabbit

Reactivity :Human, Rat

Applications :WB, IF/ICC, IP

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Background :The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is required for murine fetal development. Research studies have shown that Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of STAT3 protein.

BiowMW :~ 87 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling, MAPK Erk in Growth and Differentiation Pathway, Jak Stat ：IL-6 Receptor Signaling, Inhibition of Apoptosis, Regulation of Microtubule Dynamics, SAPK JNK Signaling Cascades

Alternative Name :APRF; Signal transducer and activator of transcription 3; Acute-phase response factor

Immunogen :A synthetic peptide of human STAT3

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of STAT3 expression in Jurkat (A), C6 (B), CHOK1 (C) whole cell lysates.