Product Name :CD91 Rabbit monoclonal antibody
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, IF/ICC, IP
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)
Background :Low density lipoprotein receptor related protein 1 ( LRP1) is a type I transmembrane receptor that mediates the endocytosis of various ligands. LRP1 plays important roles in lipid homeostasis, signaling transduction, embryonic development, and glucose metabolism. In addition, LRP1 regulates APP processing and facilitates the clearance of beta-amyloid. This finding makes LRP1 a potential therapeutic target for Alzheimer’s disease. LRP1 preprotein is proteolytically processed by furin to generate a 515 kDa extracellular α subunit and a membrane-anchored 85 kDa β subunit, which together form the mature receptor.
Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CD91 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :ESC Pluripotency and Differentiation Signaling Pathway, Regulation of Microtubule Dynamics, Translational Contral elF4 and p70 S6 Kinase, Wntβ catenin signaling, MTOR signaling
Alternative Name :A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD91
Immunogen :A synthetic peptide of human LRP1
Modification :Unmodification
