Product Name :BAX Rabbit monoclonal antibody
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, IP
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100), IP (1/10 - 1/50)
Background :Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis.
Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of BAX protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Apoptosis, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, PI3K AKT signaling, SAPK JNK Signaling Cascades, Warburg Effect
Alternative Name :BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4
Immunogen :A synthetic peptide of human Bax
Modification :Unmodification
