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ABCE1 Rabbit monoclonal antibody

货号: MB66263

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66263

Product Name :ABCE1 Rabbit monoclonal antibody

Swiss-Prot :P61221

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IP

Application_all :WB (1/500 - 1/1000), IP (1/10 - 1/50)

Background :ABCE1 (RNS4I, RLI) is a mediator of the 2-5A/RNase L pathway. The 2-5A/RNase L system is considered an essential pathway of interferon (IFN) action. In the pathway, IFN stimulation activates 2-5A synthetases which convert ATP into a set of atypical oligomers known as 2-5A. These oligomers in turn activate RNase L (RNS4), which leads to inhibition of protein synthesis by cleaving mRNAs at the 3-prime side of UpNp sequences. This inhibition necessitates the association of ABCE1 with RNase L and is dependent on the ratio between the two proteins. The 2-5A/RNase L system could also play a more general physiological role, for instance, in the regulation of RNA stability in mammalian cells.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ABCE1 protein.

BiowMW :~ 68 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RLI; RNASEL1; RNASELI; RNS4I; ATP-binding cassette sub-family E member 1; 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I

Immunogen :A synthetic peptide of human ABCE1

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ABCE1 expression in K562 (A), C6 (B), NIH3T3 (C), Hela (D) whole cell lysates.