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IKB alpha Rabbit monoclonal antibody

货号: MB66260

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

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No. :MB66260

Product Name :IKB alpha Rabbit monoclonal antibody

Swiss-Prot :P25963

Host :Rabbit

Reactivity :Human, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins. Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB. IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of IKB alpha protein.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis, Death Receptor Signaling, MAPK Erk in Growth and Differentiation Pathway, Inhibition of Apoptosis, NF-kB Signaling, T cell receptor signaling, Toll-like Receptor signaling

Alternative Name :IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3

Immunogen :A synthetic peptide of human IKB alpha

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of IKB alpha expression in Jurkat (A), C6 (B) whole cell lysates.