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NAT10 Rabbit monoclonal antibody

货号: MB66255

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66255

Product Name :NAT10 Rabbit monoclonal antibody

Swiss-Prot :Q9H0A0

Host :Rabbit

Reactivity :Human, Rat

Applications :WB, IF/ICC, IP

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Background :N-acetyltransferase 10 (NAT10), also known as human N-acetyltransferase-like protein (hALP), is an acetyltransferase which increases telomerase activity through the activation of the TERT promoter. NAT10 localizes to the midbody in late phase mitosis to help achieve cytokinesis. It has been found that DNA damage can actually increase NAT10-dependent acetylation of alpha-tubulin, resulting in increased stability of the protein. This increased stability of microtubules has been linked to the sequestration of the nuclear import factor Transportin-1 in the premature aging disease, progeria. NAT10 can also function as an acetyltransferase for both rRNA and mRNA. The acetylation of the 18 S rRNA helps in rRNA processing and ribosome biogenesis, and this process can be disrupted by opposing activity of the deacetylase SirT1 in response to stress. mRNA acetylation by NAT10 plays a role in translation efficiency and mRNA stability. NAT10 is overexpressed in many different cancer types, making it a good potential therapeutic target.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of NAT10 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ALP; KIAA1709; N-acetyltransferase 10

Immunogen :Recombinant protein of human NAT10

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of NAT10 expression in Jurkat (A), C6 (B), Hela (C) whole cell lysates.

免疫沉淀（IP）