Product Name :Fascin monoclonal antibody
Applications :WB, IHC, IF
Application_all :WB (1/500 - 1/1000), IHC (1/100 - 1/300), IF (1/100 - 1/500)
Background :Fascin is a monomeric, globular protein that plays a central role in regulating the structure and function of the cortical actin cytoskeleton . Fascin promotes cross-linkage of parallel actin filaments during the formation of cell protrusions (lamellipodia and filopodia), and therefore plays an important role in regulating cell migration. It has been reported that fascin may also regulate filopodia formation by a mechanism independent of its actin-bundling functions , though less is known about this mechanism of action. Research studies have shown that increased fascin expression is associated with increased motility and invasiveness of neoplastic cells, including breast, colon, prostate, and esophageal squamous cell carcinomas . Fascin binds to the armadillo-repeat domain of β-catenin in vitro and in vivo, and has been shown to co-localize with β-catenin and cadherins at the leading edge of migratory cells.
Product :Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of Fascin protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Actin Dynamics,
Alternative Name :FAN1; HSN; SNL; Fascin; 55 kDa actin-bundling protein; Singed-like protein; p55
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human Fascin. The exact sequence is proprietary.
Modification :Unmodification
