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CD105 monoclonal antibody

货号: MB66149
价格 1350
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :MB66149
Product Name :CD105 monoclonal antibody
Swiss-Prot :P17813
Host :Mouse
Reactivity :Human
Applications :IHC
Application_all :IHC (1/100 - 1/300)
Background :CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways . CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated CD105/endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos . Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure . The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
Product :Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CD105 protein.
BiowMW :~ 70 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :END; Endoglin; CD105
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human CD105. The exact sequence is proprietary.
Conjugate :Unconjugated
Modification :Unmodification
Immunohistochemical analysis of CD105 staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Immunohistochemical analysis of CD105 staining in human placenta formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com