Product Name :CDX2 monoclonal antibody
Application_all :IHC (1/100 - 1/300)
Background :CDX2, a homeobox domain-containing transcription factor, is a master regulator of the trophectoderm, the layer that gives rise to extra-embryonic tissues in mammalian development . CDX2 is also involved in intestinal development, and gain of expression or loss of expression has been associated with various human malignancies, such as Barrett's esophagus and colorectal cancer . Mouse embryonic stem cells deficient in CDX2 display limited hematopoietic progenitor development and altered Hox gene expression , pointing to a role for CDX2 in Hox gene regulation. CDX2 is also implicated in the aberrant expression of Hox genes in human AML cell lines .
Product :Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CDX2 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CDX3; Homeobox protein CDX-2; CDX-3; Caudal-type homeobox protein 2
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human CDX2. The exact sequence is proprietary.
Modification :Unmodification
