Product Name :CD35 monoclonal antibody
Swiss-Prot :P17927; Q2VPA4
Application_all :IHC (1/100 - 1/300)
Background :Complement receptor type 1`(CR1; CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells, neutrophils, monocytes and renal podocytes. As a component of the host innate immune system, CR1/CD35 expressed on neutrophils and monocytes binds to ligands coated with the complement opsonins, C3b and C4b, which facilitates phagocytosis and production of proinflammatory cytokines. CR1/CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for Factor-I-mediated cleavage and inactivation of C3b and C4b.
Product :Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CD35 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CR1; C3BR; Complement receptor type 1; C3b/C4b receptor; CD35; CR1L; Complement component receptor 1-like protein; Complement C4b-binding protein CR-1-like protein
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human CD35. The exact sequence is proprietary.
Modification :Unmodification
