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KSP Cadherin monoclonal antibody

货号: MB66077

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66077

Product Name :KSP Cadherin monoclonal antibody

Swiss-Prot :O75309

Host :Mouse

Reactivity :Human

Applications :IHC

Application_all :IHC (1/100 - 1/300)

Background :The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-16, also known as Ksp-cadherin, is a type I membrane protein which is kidney-specific. Cadherin-16 is expressed exclusively in the basolateral membrane of renal tubular epithelial cells. The human Ksp-cadherin gene (cadherin-16) maps to chromosome 16q22.1. The mouse Ksp-cadherin gene was localized to a highly syntenic region of distal chromosome 8.

Product :Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of KSP Cadherin protein.

BiowMW :~ 89 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cadherin-16; Kidney-specific cadherin; Ksp-cadherin

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human KSP Cadherin. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemical analysis of KSP Cadherin staining in human chromophobe cell renal carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.