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Survivin monoclonal antibody

货号: MB65979
价格 1350
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :MB65979
Product Name :Survivin monoclonal antibody
Swiss-Prot :O15392
Host :Mouse
Reactivity :Human, Mouse, Rat
Applications :WB, IHC
Application_all :WB (1/1000 - 1/2000), IHC (1/200 - 1/500)
Background :Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy. Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division. This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase. Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth.
Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of Survivin protein.
BiowMW :~ 16 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
Immunogen :Recombinant protein corresponding to human Survivin.
Conjugate :Unconjugated
Modification :Unmodification
Western blot analysis of Survivin expression in Hela (A), 293 (B), PC12 (C) whole cell lysates.
Immunohistochemical analysis of Survivin staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com