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CD33 monoclonal antibody

货号: MB65774

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB65774

Product Name :CD33 monoclonal antibody

Swiss-Prot :P20138

Host :Mouse

Reactivity :Human

Applications :IF, FC

Application_all :IF (1/50 - 1/200)

Background :CD33, a type I transmembrane protein, is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily, and human CD33 binds preferentially to alpha-2, 6-linked sialic acid. Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain, inhibiting cellular function such as phagocytosis. In addition, CD33 is also involved in other processes, such as adhesion. Due to its exclusive expression on hematopoietic cells, particularly the myeloid lineage and their progenitors, CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML). CD33 may also be involved in Alzheimer’s Disease.

Product :Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Purification&Purity :The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes human CD33

BiowMW :~ 39 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SIGLEC3; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33

Immunogen :Native purified human CD33.

Conjugate :Unconjugated

Modification :Unmodification

Flow cytometric analysis of HEL cells using Anti-CD33 Antibody, followed by anti-mouse IgG PE.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）