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SDCBP (Syntenin) mouse monoclonal antibody (KU)

货号: MB4016

价格：￥ ——

货期：现货（1-2个工作日）

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No. :MB4016

Product Name :SDCBP (Syntenin) mouse monoclonal antibody (KU)

Swiss-Prot :O00560

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :IHC, WB

Application_all :WB 1:500~2000, IHC 1:150

Background :Syntenin-1 (MDA9, SDCBP) is a member of the PDZ family of proteins, defined by the presence of a PDZ protein interaction domain. Syntenin-1, via its PDZ domain, functions as a scaffold adaptor protein that regulates numerous signal transduction pathways, including FAK, Src, TGFβR1, EGFR, and IGF1R. Aberrantly elevated expression of syntenin-1 has been found in various cancers, and has been linked to growth and invasion of tumor cells. In the central nervous system, syntenin-1 has been shown to mediate neuron dendrite protrusion and spine formation through its interaction with syndecan and Rheb. Syntenin-1 is also a key component of the syndecan/syntenin/ALIX pathway which has been shown to directly contribute to the formation and internalization of exosomes.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG1

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Syntenin-1; Melanoma differentiation-associated protein 9 (MDA-9); Pro-TGF-alpha cytoplasmic domain-interacting protein 18 (TACIP18); Scaffold protein Pbp1; Syndecan-binding protein 1; SDCBP

Immunogen :Full length human recombinant protein of human SDCBP(NP_005616) produced in HEK293T cell.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of SDCBP (Syntenin) mouse monoclonal antibody at 1:500 dilution. Lane1:A549 whole cell lysate(30ug)

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-SDCBP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min)