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Lamin A/C (5D12) monoclonal antibody

货号: MB0181

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0181

Product Name :Lamin A/C (5D12) monoclonal antibody

Swiss-Prot :P02545

Host :Mouse

Reactivity :Human

Applications :WB IF

Application_all :WB: 1:1000 IF: 1:50~200

Background :The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of Lamin A/C and does not cross-react with related proteins.

BiowMW :Predicted band size:74, 65KDa Observed band size:74, 65KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Immunogen :Purified recombinant human LMNA protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Lamin A/C in MCF7,A549 and Hela cell lysates using Lamin A/C mouse mAb (1:1000 diluted).

Immunofluorescent analysis of A549 cells fixed with 4% Paraformaldehyde and using anti-Lamin A/C mouse mAb (dilution 1:200).