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Integrin β3 (N-terminus) monoclonal antibody

货号: MB0145

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0145

Product Name :Integrin β3 (N-terminus) monoclonal antibody

Swiss-Prot :P05106

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000

Background :Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of Integrin β3 and does not cross-react with related proteins

BiowMW :Predicted band size :87KDa Observed band size:110KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Integrin beta-3; Platelet membrane glycoprotein IIIa; Short name=GPIIIa; CD_antigen=CD61; ITGB3; GP3A; CD61; GPIIIa;

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human Integrin β3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of ITGB3 in 15ug & 25ug Leukocyte cell lysate (1:1000 diluted) .

Integrin β3 Mediates the Endothelial-to-Mesenchymal Transition via the Notch Pathway

JournalCellular Physiology And Biochemistry

ApplicationIF,WB

IF0

SpeciesHuman

PMID30196283