产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

TNFRSF10B / DR5 monoclonal antibody

货号: MB0135

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0135

Product Name :TNFRSF10B / DR5 monoclonal antibody

Swiss-Prot :O14763

Host :Mouse

Reactivity :Human,Mouse

Applications :WB ICC

Application_all :WB: 1:500~2000 ICC: 1:50~200

Background :Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the “death domain,” that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins

BiowMW :Predicted band size:40/48KDa Observed band size:40/48KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Necrotic Cell Death,Death Receptor Signaling,

Alternative Name :Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; UNQ160/PRO186

Immunogen :Recombinant full length Human TNFRSF10B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of TNFRSF10B / DR5 antibody in Mouse kindey, Mouse brain, HCT116 and Hela cell lysates using TNFRSF10B antibody (1:500-1:2000 diluted) .

Knockdown of TNF receptor-associated factor 2 (TRAF2) modulates in vitro growth of TRAIL-treated prostate cancer cells

JournalBiomedicine & Pharmacotherapy

ApplicationWB

IF6.529

SpeciesHuman

PMID28667915
Programmed delivery of cyclopeptide RA-V and antisense oligonucleotides for combination therapy on hypoxic tumors and for therapeutic self-monitoring

JournalBiomaterials Science

Application

IF6.183

Species

PMID31687671
Abnormal Expression of TRAIL Receptors in Decidual Tissue of Chlamydia trachomatis-Infected Rats During Early Pregnancy Loss

JournalReproductive Sciences

ApplicationIHC

IF3.06

SpeciesRat

PMID27852922
2-Deoxy- d -glucose enhances TRAIL-induced apoptosis in human gastric cancer cells through downregulating JNK-mediated cytoprotective autophagy

JournalCancer Chemotherapy And Pharmacology

ApplicationWB

IF2.967

SpeciesHuman

PMID29383484