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DNA-PKCS monoclonal antibody

货号: MB0134

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0134

Product Name :DNA-PKCS monoclonal antibody

Swiss-Prot :P78527

Host :Mouse

Reactivity :Human

Applications :WB IP ICC

Application_all :WB: 1:1000 ICC: 1:50~100 IP: 1:50~100

Background :The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. All of the members of the PIK-related kinases are also over 270 kDa. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of DNA-PKCS and does not cross-react with related proteins

BiowMW :Predicted band size:450KDa Observed band size:450KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,Cell Cycle G2 M DNA Damage Signaling Pathway,

Alternative Name :DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460; PRKDC; HYRC; HYRC1

Immunogen :Recombinant full length Human DNA-PKCS.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of PRKDC in Hela & K562 cell lysates using PRKDC antibody (1:1000 diluted) .

Immunocytochemistry stain of Hela using PRKDC antibody (1:100).

免疫沉淀（IP）