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NUP98 monoclonal antibody

货号: MB0111

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0111

Product Name :NUP98 monoclonal antibody

Swiss-Prot :P52948

Host :Mouse

Reactivity :Human

Applications :WB IP

Application_all :WB: 1:1000 IP: 1:50~1:200

Background :Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of NUP98 and does not cross-react with related proteins

BiowMW :Predicted band size:98kDa Observed band size:98kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Nuclear pore complex protein Nup98; 98 kDa nucleoporin; Nucleoporin Nup98; Nuclear pore complex protein Nup96; 96 kDa nucleoporin; Nucleoporin Nup96; ADIR2; NUP96; NUP196

Immunogen :Recombinant full length Human NUP98.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of NUP98 in Hela, Jurkat&MCF7 cell lysates using NUP98 antibody (1:1000 diluted) .