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TORC1 (N-terminus) monoclonal antibody

货号: MB0104

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0104

Product Name :TORC1 (N-terminus) monoclonal antibody

Swiss-Prot :Q6UUV9

Host :Mouse

Reactivity :Human

Applications :WB FC ICC IP

Application_all :WB: 1:1000 ICC: 1:100~300 IP: 1:50~200 FC: 1:50~100

Background :Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)

Product :Mouse IgM, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins

BiowMW :Predicted band size:69KDa Observed band size:69KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1; MECT1; TORC1; WAMTP1

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human TORC1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of TORC1 (N-terminus) antibody in Hela&Jurkat lysates using TORC1 (N-terminus) antibody (1:1000 diluted) .

Flow Cytometry analysis of K562 cells stained with TORC1(N-terminus) (red, 1/100 dilution), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG.

Immunocytochemistry stain of Hela using TORC1 antibody (1:300).

Immunoprecipitation analysis of Hela cell lysate using CRTC1 antibody.