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CDK5 (N-terminus) monoclonal antibody

货号: MB0101

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0101

Product Name :CDK5 (N-terminus) monoclonal antibody

Swiss-Prot :Q00535

Host :Mouse

Reactivity :Human

Applications :WB ICC

Application_all :WB: 1:1000 ICC: 1:100~200

Background :Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk5 is thought to be involved in the G1-S transition of the cell cycle and is highly expressed in mature neurons. Activity of Cdk5 increases significantly during neuronal differentiation. Cdk5 has been postulated to be a neurofilament or tau protein kinase, based on its ability to phosphorylate these proteins in vitro.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of CDK5 and does not cross-react with related proteins

BiowMW :Predicted band size:36KDa Observed band size:36KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Dopamine Signaling in Parkinson's Disease Plathway,

Alternative Name :Cdk 5; Cdk5; CDK5; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Cyclin-dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit;

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human CDK5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of CDK5 (N-terminus) antibody in Jurkat, K562&Hela lysates using CDK5 (N-terminus) antibody (1:1000 diluted) .