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SMC1A (C-terminus) monoclonal antibody

货号: MB0008

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0008

Product Name :SMC1A (C-terminus) monoclonal antibody

Swiss-Prot :Q14683

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000

Background :Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of SMC1A(C-term) and does not cross-react with related proteins

BiowMW :Predicted band size:143KDa Observed band size:143KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8; SMC1A; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1

Immunogen :Synthetic peptide, corresponding to the C-terminus of Human SMC1A.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of SMC1A in MOLT-4, U87 MG&HelaNE cell lysate (1:1000 diluted)