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c-Jun monoclonal antibody

货号: MB0004

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0004

Product Name :c-Jun monoclonal antibody

Swiss-Prot :P05412

Host :Mouse

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:1000

Background :The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of JUN and does not cross-react with related proteins

BiowMW :Predicted band size:36KDa Observed band size:45KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :MAPK Erk in Growth and Differentiation Pathway,

Alternative Name :JUN; p39; V-jun avian sarcoma virus 17 oncogene homolog; Proto-oncogene c-Jun; AP1; Activator protein 1; Transcription factor AP-1

Immunogen :Recombinant full length Human c-Jun.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of JUN in :293 &3T3 cell lysates (1:1000 diluted) .

Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells

JournalToxicology Letters

ApplicationWB

IF3.569

SpeciesRat

PMID