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TWIST1 monoclonal antibody

货号: LM1040

价格：￥ 1500

货期：现货（1-2个工作日）

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No. :LM1040

Product Name :TWIST1 monoclonal antibody

Swiss-Prot :Q15672

Host :Mouse

Reactivity :Human,Mouse

Applications :WB IHC ICC FC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.

Product :Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TWIST1 monoclonal antibody detects endogenous levels of TWIST1 protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of Soluble Factors to EMT,

Alternative Name :Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; BHLHA38; TWIST

Immunogen :Purified recombinant fragment of human TWIST1 (AA: 9-74) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TWIST1 monoclonal antibody Lane1:NIH/3T3 whole cell lysate Lane2:Jurkat whole cell lysate Lane2:Hela whole cell lysate Lane2: A549 whole cell lysate Lane2:Raji whole cell lysate Lane2:OCM1 whole cell lysate

A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells

JournalCell And Tissue Research

ApplicationWB,IHC,IF

IF5.249

SpeciesHuman,Mouse

PMID23703635
RETRACTED: Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells

JournalInternational Journal Of Biochemistry & Cell Biology

ApplicationWB,IHC

IF5.085

SpeciesMouse

PMID
Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells

JournalCellular Signalling

ApplicationIHC

IF4.315

SpeciesMouse

PMID22570869
Arsenic trioxide: marked suppression of tumor metastasis potential by inhibiting the transcription factor Twist in vivo and in vitro

JournalJournal Of Cancer Research And Clinical Oncology

ApplicationWB

IF3.332

SpeciesRat

PMID
Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma

JournalFrontiers in Oncology

ApplicationIHC,WB

IF6.244

SpeciesHuman,Mouse

PMID34178646