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DAX1 polyclonal antibody（KU）

货号: GCP65

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :GCP65

Product Name :DAX1 polyclonal antibody（KU）

Swiss-Prot :P51843

Host :Rabbit

Reactivity :Human,Pig

Applications :WB IF IHC

Application_all :WB: 1:1000~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :DSS-AHC critical region on the X chromosome protein 1 (DAX1) is an orphan nuclear receptor encoded by the nuclear receptor subfamily 0 group B member 1 (NR0B1) gene. DAX1 possesses an atypical DNA binding domain that allows it to form heterodimeric complexes with DNA binding partners and repress transcriptional activity. During development, DAX1 is important for establishment of the hypothalamic-pituitary-adrenal gonadal axis. The receptor is essential for development of several important hormone-producing organs that determine this axis, including the adrenal glands, pituitary, hypothalamus, and the male and female reproductive organs. Research studies suggest that DAX1 plays a role in maintenance of pluripotency in embryonic stem cells. Loss of DAX1 function through deletion or mutation results in adrenal insufficiency and hypogonadotropic hypogonadism, while duplication of the NR0B1 gene on the X-chromosome causes dosage-sensitive sex reversal.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DAX1 polyclonal antibody detects endogenous levels of DAX1 protein.

BiowMW :~ 48 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Nuclear receptor subfamily 0 group B member 1; DSS-AHC critical region on the X chromosome protein 1; Nuclear receptor DAX-1

Immunogen :Synthetic peptide, corresponding to Human DAX1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of DAX1 polyclonal antibody at 1:2000 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:The Kidney tissue lysate of Pig(40ug)

Immunofluorescence analysis of A549 cells using DAX1 antibody at dilution of 1:50.