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Tet1 (C-term) polyclonal antibody

货号: BZ12161

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BZ12161

Product Name :Tet1 (C-term) polyclonal antibody

Swiss-Prot :Q3URK3

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB: 1:2000

Background :Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Tet1 (C-term) polyclonal antibody detects endogenous levels of Tet1 protein.

BiowMW :~ 219 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Methylcytosine dioxygenase TET1; CXXC-type zinc finger protein 6; Ten-eleven translocation 1 gene protein homolog; Cxxc6; Kiaa1676

Immunogen :This mouse Tet1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1845-1879 amino acids from the C-terminal region of mouse Tet1.

Conjugate :Unconjugated

Modification :Unmodification

Anti-Tet1 Antibody (C-term)at 1:2000 dilution + F9 whole cell lysates Lysates/proteins at 20 µg per lane.

TET1 inhibits EMT of ovarian cancer cells through activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2

JournalGynecologic Oncology

ApplicationWB

IF4.393

SpeciesHuman

PMID28851501
The Tet1 and histone methylation expression pattern in dairy goat testis

JournalTheriogenology

ApplicationICC,IHC

IF2.299

SpeciesGoat

PMID25662202
A postpartum enriched environment rescues impaired cognition and oxidative markers in aged mice with gestational inflammation

JournalBrain and Behavior

ApplicationWB

IF3.405

SpeciesMouse

PMID36409568