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PGD synthase (M115) polyclonal antibody（KU）

货号: BS9543

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS9543

Product Name :PGD synthase (M115) polyclonal antibody（KU）

Swiss-Prot :O60760

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver (1). Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively. Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity. Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PGD synthase (M115) polyclonal antibody endogenous levels of PGD synthase protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Hematopoietic prostaglandin D synthase; H-PGDS; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase; HPGDS; GSTS; PGDS; PTGDS2

Immunogen :Synthetic peptide, corresponding to amino acids 55-175 of PGD synthase

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of PGD synthase (M115) polyclonal antibody at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:HepG2 whole cell lysate(40ug) Lane5:C6 whole cell lysate(40ug) Lane6:BV2 whole cell lysate(40ug)