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PAK5 (E693) polyclonal antibody

货号: BS9193

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS9193

Product Name :PAK5 (E693) polyclonal antibody

Swiss-Prot :Q9P286

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK5 operates downstream of Cdc42 and Rac and antagonizes Rho in the pathway, leading to neurite development. PAK5 is a functional protein kinase, but, unlike PAK-I family kinases (PAK1, 2, and 3), the kinase activity of PAK5 does not seem to require the binding of CDC42. PAK5 is highly expressed in mammalian brain but is not expressed in most other tissues. PAK5 colocalizes and binds to both the actin and MT networks and its subcellular localization is regulated during cell cycle progression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PAK5 (E693) polyclonal antibody detects endogenous levels of PAK5 protein.

BiowMW :~ 90 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine/threonine-protein kinase PAK 7; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; PAK7; KIAA1264; PAK5

Immunogen :Synthetic peptide, corresponding to amino acids 660-712 of Human PAK5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PAK5 (E693) pAb at 1:500 dilution Lane1:The Brain tissue lysate of Rat(40ug) Lane2:The Brain tissue lysate of Mouse(30ug)

Immunohistochemistry (IHC) analyzes of PAK5 (E693) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer

JournalClinical and Translational Medicine

ApplicationCoIP

IF8.554

SpeciesHuman

PMID36394206
PAK5 potentiates slug transactivation of N-cadherin to facilitate metastasis of renal cell carcinoma

JournalCELLULAR SIGNALLING

ApplicationIP

IF4.8

SpeciesHuman

PMID37437827