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PI3K p110γ (L89) polyclonal antibody

货号: BS9175

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS9175

Product Name :PI3K p110γ (L89) polyclonal antibody

Swiss-Prot :P48736

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110γ expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110γ seems to have the capacity to autophosphorylate. p110 does not interact with the p85 subunits. It has been shown to be activated by α and β heterotrimeric G proteins.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PI 3-Kinase p110γ (L89) polyclonal antibody detects endogenous levels of PI 3-Kinase p110γ protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; FLJ92943; HGNC11998; LFS1; p53; p53 Cellular Tumor Antigen; p53 tumor suppressor; P53; Phosphoprotein p53; Tp53 a

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human PI3K p110γ.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of PI3K p110γ (L89) pAb in paraffin-embedded human breast carcinoma tissue at 1:50,showing strong cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of PI3K p110γ (L89) pAb in paraffin-embedded human lung carcinoma tissue at 1:50,showing strong cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.