Product Name :PHF3 (D2033) polyclonal antibody（KU）
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :PHF3 (PHD finger protein 3) is a 2039 amino acid ubiquitously expressed protein that is phosphorylated upon DNA damage by either ATM or ATR. PHF3 contains a PHD finger motif, a proline-rich region, a TFIIS domain and two bipartite nuclear localization signals. Since these motifs are frequently found in proteins involved in transcription, PHF3 may function as a transcription factor. Expression of PHF3 is significantly reduced in anaplastic astrocytomas, glioblastomas and glioblastoma cell lines, suggesting that PHF3 plays a role as a tumor suppressor. Antibodies against PHF3 are present in some patients afflicted with glioblastoma multiforme and presence of the , correlates to significantly better survival rates. There are two isoforms of PHF3 that are produced as a result of alternative splicing events.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PHF3 (D2033) polyclonal antibody detects endogenous levels of PHF3 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :PHD finger protein 3; PHF3; PHF3;
Immunogen :Synthetic peptide, corresponding to the C-terminus of Human PHF3.
Modification :Unmodification
