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STAT2 polyclonal antibody（KU）

货号: BS91285

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS91285

Product Name :STAT2 polyclonal antibody（KU）

Swiss-Prot :P52630

Host :Rabbit

Reactivity :Human

Applications :WB IP

Application_all :WB:1:1000~1:2000 IP:1:50~1:200

Background :Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :STAT2 polyclonal antibody detects endogenous levels of STAT2 protein.

BiowMW :~ 113 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Jak Stat ：IL-6 Receptor Signaling,

Alternative Name :STAT2, Homo sapiens interferon alpha induced transcriptional activator, interferon alpha induced transcriptional activator, ISGF 3, ISGF3, MGC59816, P113, signal transducer and activator of transcription 2 113kD, Signal transducer and activator of transcription 2, STAT113, Stat2, STAT2,

Immunogen :Synthetic peptide, corresponding to Human STAT2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Stat5a/b pAb at 1:1000 dilution Lane1:HepG2 whole cell lysate(20ug) Lane2:U-87MG whole cell lysate(20ug)

Immunoprecipitation of SGC7901 cell lysates using STAT2 pAb (Sepharose Bead Conjugate)#BD0048 (lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate)#BD0048 (lane 4 and lane 5) .Lane 1 is 30% input. The western blot was probed using STAT2 pAb #BS91285.

Local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata

JournalAntiviral Research

ApplicationWB

IF4.101

SpeciesHuman

PMID20797409