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FBXW7 polyclonal antibody

货号: BS90499

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS90499

Product Name :FBXW7 polyclonal antibody

Swiss-Prot :Q969H0

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB 1:500 - 1:1000

Background :Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity :FBXW7 polyclonal antibody detects endogenous levels of FBXW7 protein.

BiowMW :~ 79 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FBW7; FBX30; SEL10; F-box/WD repeat-containing protein 7; Archipelago homolog; hAgo; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; SEL-10; hCdc4

Immunogen :Recombinant full length protein of human Cdc4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Cdc4 expression in mouse heart (A) whole cell lysates.