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Cathepsin D polyclonal antibody

货号: BS90201

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS90201

Product Name :Cathepsin D polyclonal antibody

Swiss-Prot :P07339

Host :Rabbit

Reactivity :Human

Applications :WB IHC IP

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200

Background :The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides. The promoter region of the cathepsin D gene contains five Sp1 binding sites and four AP-2 binding sites.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity :Cathepsin D polyclonal antibody detects endogenous levels of Cathepsin D protein.

BiowMW :~ 28, 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cathepsin D; Cathepsin D light chain; Cathepsin D heavy chain; CTSD; CPSD

Immunogen :Synthetic peptide, corresponding to Human Cathepsin D.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cathepsin D polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate(40ug) LaneB:A375 whole cell lysate(40ug) LaneC:H460 whole cell lysate(40ug)

Immunohistochemical analysis of Cathepsin D staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system.

SERTAD1 Sensitizes Breast Cancer Cells to Doxorubicin and Promotes Lysosomal Protein Biosynthesis

JournalBiomedicines

ApplicationWB

IF6.081

SpeciesHuman

PMID35625886