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Trx2 polyclonal antibody

货号: BS8545

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS8545

Product Name :Trx2 polyclonal antibody

Swiss-Prot :Q99757

Host :Rabbit

Reactivity :Human,Mouse,Rat,Bovine

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Thioredoxin 2 (Trx-2) is a small redox protein that is localized to the mitochondria and is essential for cell viability, playing a crucial role in the scavenging of ROS in mitochondria and regulating the mitochondrial apoptosis signaling pathway. Trx reductases (TrxR1 and TrxR2) are ubiquitously expressed flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Trx2 polyclonal antibody detects endogenous levels of Trx2 protein.

BiowMW :~ 13 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; Thioredoxin 2; Thioredoxin2; TXN2; TRX-2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Trx2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Trx2 expression in HEK293T (A), Hela (B), mouse liver (C), rat lung (D), rat liver (E) whole cell lysates.

Methionine sulfoxide reductase A deficiency exacerbates progression of kidney fibrosis induced by unilateral ureteral obstruction

JournalFree Radical Biology And Medicine

ApplicationWB

IF6.17

SpeciesMouse

PMID26210777