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RALB polyclonal antibody

货号: BS8542

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS8542

Product Name :RALB polyclonal antibody

Swiss-Prot :P11234

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200

Background :Ral A and Ral B constitute a distinct subfamily of Ras-related GTPases (i.e., GDP/GTP binding proteins). Ral proteins are activated by a unique nucleotide exchange factor, Ral GDS, and deactivated by a distinct GTPase-activating protein. Unlike Ras proteins, Ral A and Ral B fail to induce transformed foci when activated variants are expressed in various recipient cells. A potential downstream target of Ral, designated Ral BP-1, has been shown to contain a Rho-GTPase-activating domain. This Rho-GTPase-activating domain interacts preferentially with the Rho family member Cdc42. A Ras/Ral signaling pathway has been reported to mediate phospholipase D (PLD) activation by v-Src, thus indicating PLD as another downstream target of Ral A.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RALB polyclonal antibody detects endogenous levels of RALB protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ras-related protein Ral-B; RALB

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALB (NP_002872.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using RALB antibody at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded human liver damage using RALB antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human colon carcinoma using RALB antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human gastric cancer using RALB antibody at dilution of 1:100 (40x lens).