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PIAS1 polyclonal antibody

货号: BS8489

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS8489

Product Name :PIAS1 polyclonal antibody

Swiss-Prot :O75925

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IF/ICC

Application_all :WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200

Background :This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :Refer to figures

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PIAS1;DDXBP1;GBP;GU/RH-II;ZMIZ3

Immunogen :Recombinant fusion protein of human PIAS1(NP_057250.1).

Conjugate :Unconjugated

Modification :Unmodification

Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cells using PIAS1 antibody . Green: GFP-RNF168 fusion protein expression for DNA damage marker. Blue: DAPI for nuclear staining. RNF168 can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.

Immunofluorescence analysis of U2OS cells using PIAS1 antibody . Blue: DAPI for nuclear staining.

PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis

JournalCell Death & Disease

ApplicationWB,IP

IF5.959

SpeciesHuman

PMID24052079