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RBP2 polyclonal antibody

货号: BS8380

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS8380

Product Name :RBP2 polyclonal antibody

Swiss-Prot :P50120

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background :Rb (retinoblastoma protein) is a potent transcriptional regulator that is directly involved with events such as entry into cell division and formation of heterochromatin. RBP2 (Retinoblastoma-binding protein 2), also known as RBBP2, JARID1A (Jumonji/ARID domain-containing protein 1A) or KDM5A, is a nuclear protein that belongs to the JARID1 histone demethylase family. Expressed ubiquitously, RBP2 functions as a histone demethylase that, in conjunction with other proteins, binds directly to the viral-binding domain of Rb, thereby regulating Rb-mediated cell proliferation events. In addition, RBP2 can bind to the Rb-interacting protein rhombotin-2 (LMO2) and, through this interaction, can indirectly modulate Rb activity. Via its demethylase activity, RBP2 can remove methyl residues from Histone H3, thus playing a crucial role in the histone code. RBP2 contains one ARID domain, three PHD-type zinc fingers, one JMJN domain and one JMJC domain through which it conveys its enzymatic activity. Multiple isoforms of RBP2 exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RBP2 polyclonal antibody detects endogenous levels of RBP2 protein.

BiowMW :~ 16 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Retinol-binding protein 2; Cellular retinol-binding protein II; CRBP-II; RBP2; CRBP2

Immunogen :Recombinant full length Human RBP2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cells, using RBP2 antibody.

Immunohistochemistry of paraffin-embedded human liver injury using RBP2 antibody at dilution of 1:100 (x40 lens).

Immunohistochemistry of paraffin-embedded human gastric using RBP2 antibody at dilution of 1:100 (x40 lens).

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