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MMRN1 polyclonal antibody

货号: BS8331

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS8331

Product Name :MMRN1 polyclonal antibody

Swiss-Prot :Q13201

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IF/ICC

Application_all :WB: 1:500-1:2000 IF/ICC: 1:50-1:100

Background :Multimerin-1 is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MMRN1 polyclonal antibody detects endogenous levels of MMRN1 protein.

BiowMW :~ 178 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ECM; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN 4; EMILIN4; Endothelial cell multimerin 1; Glycoprotein Ia; GlycoproteinIa; GPIa; MMRN 1; MMRN; Multimerin 1; Multimerin-1; Multimerin1; MMRN1_HUMAN.

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1083-1228 of human MMRN1 (NP_031377.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of various lysates, using MMRN1 Rabbit pAb at 1:1000 dilution.

Immunofluorescence analysis of U2OS cells using MMRN1 antibody. Blue: DAPI for nuclear staining.