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C4BPB polyclonal antibody

货号: BS8157

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS8157

Product Name :C4BPB polyclonal antibody

Swiss-Prot :P20851

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:100

Background :Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven α chains and one β chain. C4BP functions as a cofactor for C3β inactivator in the cleavage of C3β, and accelerates the decay of C4βC2α (C3 convertase) by acting as a cofactor in the cleavage of C4β by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family,can bind to overlapping C4β binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurances of bacterial opsonization and phagocytosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :C4BPB polyclonal antibody detects endogenous levels of C4BPB protein.

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C4b-binding protein beta chain; C4BPB

Immunogen :Synthetic peptide, corresponding to Human C4BPB.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of C4BPB polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate(30ug) LaneB:H1688 whole cell lysate(30ug) LaneC:MCF-7 whole cell lysate(30ug) LaneD:The Liver tissue lysate of Mouse(30ug) LaneE:The Liver tissue lysate of Rat(30ug)

Immunohistochemical analysis of C4BP beta staining in human colorectal cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of C4BP beta staining in HEK293T cells.