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IL12RB1 polyclonal antibody

货号: BS8052

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS8052

Product Name :IL12RB1 polyclonal antibody

Swiss-Prot :P42701

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB 1:500 - 1:2000

Background :IL-12, a heterodimeric cytokine composed of two disulfide-bonded glycoprotein subunits, p35 and p40, has pleiotrophic activities including stimulation of the proliferation of activated T and NK cells, induction of IFN-g production by PBMCs, enhancement of the lytic activity of NK/LAK cells and promotion of T-helper (Th) 1 cell responses. The T cell response to IL-12 is mediated through two receptor proteins, designated IL-12Rb-1 and IL-12Rb-2 (4). The genes encoding human IL-12Rb-1 and IL-12Rb-2 map to chromosomes 19p13.1 and 1p31.3-p31.2, respectively. Increased IL-12Rb-2 expression is crucial in regulating Th1 differentiation, whereas IL-12Rb-1 expression is less restricted. Inhibition of IL-12 activity may provide treatment for diseases associated with pathologic Th1 responses, such as multiple sclerosis or Crohn’s disease, while administration of recombinant IL-12 may aid in the treatment for allergic disorders and asthma.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL12RB1 polyclonal antibody detects endogenous levels of IL12RB1 protein.

BiowMW :~ 73 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-12 receptor subunit beta-1; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL-12 receptor beta component; CD_antigen=CD212; IL12RB1; IL12R; IL12RB

Immunogen :Recombinant full length protein of human CD212.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CD212 expression in A431 (A), MCF7 (B), mouse liver (C), mouse thymus (D) whole cell lysates.