Product Name :DUOX1 polyclonal antibody
Application_all :WB,1:500 - 1:1000
Background :The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :DUOX1 polyclonal antibody detects endogenous levels of DUOX1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DUOX; LNOX1; THOX1; Dual oxidase 1; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; Thyroid oxidase 1
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DUOX1.
