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IRF8 polyclonal antibody

货号: BS7865

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS7865

Product Name :IRF8 polyclonal antibody

Swiss-Prot :Q02556

Host :Rabbit

Reactivity :Human

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:200

Background :ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-γ-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-γ and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-α and IFN-β.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IRF8 polyclonal antibody detects endogenous levels of IRF8 protein.

BiowMW :~ 47 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :H ICSBP; H-ICSBP; HGNC:5358; HGNC5358; HICSBP; ICSBP 1; ICSBP; ICSBP1; ICSBP1; Interferon Consensus Sequence Binding Protein 1; Interferon consensus sequence binding protein; Interferon consensus sequence-binding protein; Interferon Regulatory Factor 8; IRF 8; IRF-8; IRF8; IRF8; IRF8_HUMAN; MYLS;

Immunogen :Recombinant full length Human IRF8.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of THP-1 cells, using IRF8 antibody.

Immunofluorescence analysis of A549 cells using IRF8 antibody.