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INSL3 polyclonal antibody

货号: BS7819

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS7819

Product Name :INSL3 polyclonal antibody

Swiss-Prot :P51460

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :IHC-P IF/ICC ELISA

Application_all :IHC-P 1:50 - 1:100 IF/ICC 1:50 - 1:100 ELISA 1:5000 - 1:10000

Background :Insulin-like factor 3 (INSL3), also designated Leydig insulin-like peptide (Ley IL) and Relaxin-like factor (RLF), is a peptide hormone in the Relaxin family which is secreted from the testicular Leydig cells and ovarian theca interna cells. INSL3 is involved in gonadal and other physiological processes. Structurally similar to Relaxin and insulin, INSL3 differs from the two in that it signals through a G protein-coupled receptor, LGR8. INSL3/LGR8 signaling is involved in gubernaculum development and transabdominal testicular descent during development. Abnormal INSL3 production or action by the fetal testis causes cryptorchidism, a developmental defect of the urogenital tract in human males wherein the testis do not descend into the scrotum during embryonic development. Infertility and the development of germ-cell tumors are two potential risks for individuals with cryptorchidism.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :INSL3 polyclonal antibody detects endogenous levels of INSL3 protein.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :INSL 3; INSL-3; INSL3_HUMAN; Insulin like 3; Insulin-like 3 A chain; Ley IL; Ley-I-L; Leydig insulin like peptide; Leydig insulin-like peptide; Relaxin like factor; Relaxin-like factor; RLF; RLNL

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 ofhuman INSL3 (NP_005534.2).

Conjugate :Unconjugated

Modification :Unmodified

Immunohistochemistry analysis of paraffinembedded Human prostate using INSL3 pAb at dilution of 1:100 (40xlens).

Intronic miR-140-5p contributes to beta-cypermethrin-mediated testosterone decline

JournalScience Of The Total Environment

ApplicationWB

IF7.963

SpeciesRat,Mouse

PMID34794910
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline

JournalJOURNAL OF HAZARDOUS MATERIALS

ApplicationWB

IF12.2

SpeciesRat

PMID39002476