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HFE2 polyclonal antibody

货号: BS7548
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS7548
Product Name :HFE2 polyclonal antibody
Swiss-Prot :Q6ZVN8
Host :Rabbit
Reactivity :Mouse, Rat
Applications :WB
Application_all :WB,1:500 - 1:2000
Background :The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Polyclonal Antibodies
BiowMW :52kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :HFE2;HFE2A;HJV;JH;RGMC
Immunogen :Recombinant fusion protein of human HFE2(NP_998818.1).
Conjugate :Unconjugated
Modification :Unmodification
Western blot analysis of extracts of Rat heart, using HFE2 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 90s.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com