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SETD2 polyclonal antibody

货号: BS7519

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS7519

Product Name :SETD2 polyclonal antibody

Swiss-Prot :Q9BYW2

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC, IP

Application_all :WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|IP,1:50 - 1:200

Background :Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :288KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SETD2;HBP231;HIF-1;HIP-1;HSPC069;HYPB;KMT3A;LLS;SET2;p231HBP

Immunogen :A synthetic peptide of human SETD2(NP_054878.5).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of Mouse spleen, using SETD2 antibody at 1:913 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 90s.

Histone methyltransferase SETD2 is required for meiotic maturation in mouse oocyte

JournalJournal Of Cellular Physiology

ApplicationWB,IF

IF5.546

SpeciesMouse

PMID30078214
A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation

JournalEpigenetics

ApplicationWB

IF4.251

SpeciesMouse

PMID33135541
SETD2 reduction adversely affects the development of mouse early embryos

JournalJournal Of Cellular Biochemistry

ApplicationIF,WB

IF4.237

SpeciesMouse

PMID31407364
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models

Journal10.1016/j.ijbiomac.2024.136767

ApplicationIF,WB

IF7.7

SpeciesRat,Mouse

PMID39476923