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TTR polyclonal antibody

货号: BS7273

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS7273

Product Name :TTR polyclonal antibody

Swiss-Prot :P02766

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IHC,IF

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background :Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermed-iate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TTR polyclonal antibody detects endogenous levels of TTR protein.

BiowMW :~ 16 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Amyloid polyneuropathy; Amyloidosis I; ATTR; Carpal tunnel syndrome 1; CTS; CTS1; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; HsT2651; PALB; Prealbumin amyloidosis type I; Prealbumin; Senile systemic amyloidosis; TBPA; Thyroxine binding prealbumin; Transthyretin; TTHY_HUMAN; TTR; TTR protein;

Immunogen :Recombinant full length Human TTR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TTR polyclonal antibody

Immunohistochemistry (IHC) analysis of TTR polyclonal antibody in paraffin-embedded Human Thyroid Cancer tissue.

DEHP reduces thyroid hormones via interacting with hormone synthesis-related proteins, deiodinases, transthyretin, receptors, and hepatic enzymes in rats

JournalEnvironmental Science And Pollution Research

ApplicationWB,IP

IF2.914

SpeciesRat

PMID25913319
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism

JournalScience Of The Total Environment

ApplicationWB

IF6.551

SpeciesRat

PMID33250241
P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats

JournalCellular Physiology And Biochemistry

ApplicationWB

IF0

SpeciesRat

PMID29462796