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LGR4 polyclonal antibody

货号: BS72418

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS72418

Product Name :LGR4 polyclonal antibody

Swiss-Prot :Q9BXB1

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB 1:1000 - 1:3000 IF 1:50 - 1:200

Background :Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LGR4 polyclonal antibody detects endogenous levels of LGR4 protein.

BiowMW :~ 109 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BNMD17;GPR48

Immunogen :Recombinant protein of human LGR4

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using LGR4 antibody.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）