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N-Cadherin polyclonal antibody

货号: BS72312

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS72312

Product Name :N-Cadherin polyclonal antibody

Swiss-Prot :P19022

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:100

Background :Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2-terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxyterminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P-cadherin and cadherin-5.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :N-Cadherin polyclonal antibody detects endogenous levels of N-Cadherin protein.

BiowMW :140kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,Contribution of Soluble Factors to EMT,Adherens Junction signaling,

Alternative Name :Cadherin2; Cadherin 2; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD325; CDH2; CDHN; NCAD

Immunogen :A synthetic peptide of human CDH2

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using CDH2 antibody at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded mouse liver using CDH2 antibody at dilution of 1:100 (40x lens).

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling

JournalGenes & Diseases

ApplicationWB

IF6.8

SpeciesHuman

PMID