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Smad4 polyclonal antibody

货号: BS7225

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS7225

Product Name :Smad4 polyclonal antibody

Swiss-Prot :Q13485

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IHC,IF

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background :Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Smad4 polyclonal antibody detects endogenous levels of Smad4 protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoint,Contribution of Soluble Factors to EMT,hippo Signaling,

Alternative Name :Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4; SMAD4; DPC4; MADH4

Immunogen :Recombinant full length Human Smad4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Smad4 polyclonal antibody

Immunofluorescence analysis of U2OS cells, using Smad4 polyclonal antibody

The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy

JournalDrug Design Development and Therapy

ApplicationIHC,IF

IF4.162

SpeciesMouse

PMID35308255