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SLP-76 polyclonal antibody

货号: BS7224

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS7224

Product Name :SLP-76 polyclonal antibody

Swiss-Prot :Q13094

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB 1:500 - 1:2000

Background :Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SLP-76 polyclonal antibody detects endogenous levels of SLP-76 protein.

BiowMW :~ 75 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,T cell receptor signaling,

Alternative Name :SH2 domain-containing leukocyte protein of 76 kDa (SLP-76) is a hematopoietic adapter protein that is important in multiple biochemical signaling pathways and necessary for T cell development and activation (1). ZAP-70 phosphorylates SLP-76 and LAT a

Immunogen :Recombinant full length Human SLP-76.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of SLP-76 polyclonal antibody